The antiinflammatory activity of cfr methanol extract was evaluated in. Antiinflammatory diet while there is no specific diet that people with rheumatoid arthritis ra, should follow, researchers have identified certain foods that can help control inflammation. This thesis focuses on the anti inflammatory activity of honey. Emphasis was put on identifying the mode of action of the antiinflammatory component, creating an in vitro assay to measure the antiinflammatory activity of individual honeys and attempting to identify and characterise the. An overview on antiinflammatory properties and chemo. Gokulan, n 2009 a study on anti inflammatory and analgesic activity of thandrikkai chooranam and linga chendooram.
The antiinflammatory activity of methanolic extracts of. Characterisation of a novel endogenous antiinflammatory. Designing xanthohumol and other natural productsdirected antiinflammatory and anticancer agents and exploring their action mechanisms. Aniya y, koyama t, miyagi c, miyahira m, inomata c, kinoshita s, ichiba t 2004. Aug 21, 2018 the present studies were designed to evaluate the anti inflammatory and analgesic activity of ethanolic extract of vitex altissima stem bark peacock chaste tree. Section i discusses the background of thesis with respect to the mechanisms of mucosal damage by nsaid, the interaction between nsaid and h pylori, and the interaction between nsaid and anti rheumatoid secondline drugs. The aqueous extract has shown significant p pdf oct 2006 introduction medicinal plants with antiinflammatory activity are owe their activity flower and vane, 1974. Assessment of the anti inflammatory activity of potentially bioactive compounds by intravital microcirculatory analysis gabriella varga ph. Yale medicine thesis digital library school of medicine. The results obtained indicate that the ethanolic extract had significant anti inflammatory activity in rats. Inflammation is a pathologic condition that includes a wide range of diseases such as rheumatic and immunemediated conditions, diabetes, cardiovascular accident, and etcetera. Hrbc method was selected for the in vitro evaluation of anti inflammatory property because the erythrocyte membrane is analogous to the lysosomal membrane 5 and its stabilization implies that the extract may as well stabilize lysosomal membranes.
Research commons at the university of waikato copyright. Antiinflammatory activity of extracts from fruits, herbs and. Tendon disorders tendinopathies are the primary reason form musculoskeletal consultation in primary care in the uk and the us. It is also reported to have insecticidal activity 17. The sdgs can only be realized with strong global partnerships and cooperation.
This thesis addresses several issues related to the pathogenesis of peptic ulcers in patients receiving nonsteroidal antiinflammatory drugs nsaid. Investigating the antiinflammatory activity of honey. The anti inflammatory effect was evaluated for plant extracts 100,200 and 500 mgkg orally using acute inflammatory model, carrageenan induced paw oedema in rats. Effect of quercetin and epigallocatechin3gallate on antiinflammatory activity in vitro and in vivo a thesis by krista m kennerly december 2016 approved by.
In vitro and in vivo antiinflammatory activities of coptosapelta. New labdane diterpenoids from leonurus japonicus and their. Antipyretic and anti inflammatory activities of dichloromethanemethanolic leaf and stem bark extracts of ximenia americana in rats and mice models gaichu daniel muthee bsc. Medicinal plants with anti inflammatory activities from selected countries and regions of africa oluwafemi o oguntibeju phytomedicine and phytochemistry group, oxidative stress research centre, department of biomedical sciences, faculty of health and wellness sciences, cape peninsula university of technology, bellville, south africa abstract. On the basis of the study the formulation showed significant in vitro antioxidant activity by terminating the actions of free radicals. I dedicate this thesis to my parents, mohamed jabeur, radhia, zayati, and my sisters sirine, houda. The antioxidant activity is believed to be responsible for the anti. Starting with the yale school of medicine ysm graduating class of 2002, the cushingwhitney medical library and ysm office of student research have collaborated on the yale medicine thesis digital library ymtdl project, publishing the digitized full text of medical student theses on the web as a valuable byproduct of yale student research efforts. The plant extract was further evaluated for anti inflammatory activities in vitro with hrbc membrane stabilizing activity, inhibition of protein denaturation and anti platelet aggregation activity spectrophotometrically. Research commons at the university of waikato copyright statement.
Injection of carrageenan was done 1 h after oral administration of the extract 100, 300, and 500 mgkg, indomethacin reference. The anti inflammatory activity of several plant extracts and isolated compounds has already been scientifically demonstrated. Antiinflammatory activity of artocarpus heterophyllus bark extracts against carragenan induced paw edema is shown in table 1. This thesis focuses on the antiinflammatory activity of honey. Ahmad, tb 2017, in vitro and in vivo antiinflammatory activity of extracts from a marine mollusc, phd thesis, southern cross. Section i discusses the background of thesis with respect to the mechanisms of mucosal damage by nsaid, the interaction between nsaid and h pylori, and the interaction between nsaid and antirheumatoid secondline drugs. Its antiinflammatory activity has not been scientifically proven in vitro or in vivo. Formulation and evaluation of solasodine transdermal patches. This thesis investigates the effects of a range of clinically important tetracyclines oxytetracycline, doxycycline, minocycline and tigecycline on the. Long term uses of nsaid cause adverse side effects. Medicinal plants and their secondary metabolites are progressively used in the treatment of diseases as a complementary medicine.
Antiinflammatory activity of aqueous extract of mirabilis. In the carrageenaninduced oedema test, the paw volumes and percentages of ages of inhibition by the alcoholic extract of pinus roxburghii sarg. Acute toxicity studies acute toxicity studies were conducted in albino rats of either sex, weighing 10050 g. Antiinflammatory activity of artocarpus heterophyllus bark.
Antiinflammatory, analgesic, and antipyretic activities. The anti inflammatory activities of the isolates were evaluated by assays for regulation of superoxide anion generation and elastase release yang et al. The aekkc 200 mgkg and 400 mgkg was studied for its antiinflammatory activity using carrageenan and histamine induced inflammation. In vitro antiinflammatory properties of selected green leafy. Pdf synthesis, antiinflammatory activity, and in vitro. The anti inflammatory activity exhibited by plant extract was dosedependent. We introduce some herbs which their anti inflammatory effects have been evaluated in. The anti inflammatory effect has been documented as early as 14 years ago when ahmadiani et al.
The antiinflammatory, analgesic, and antipyretic effects of vco were assessed. Masters thesis, government siddha medical college, palayamkottai. Certain types of injury trigger a sustained inflammatory. Antiinflammatory activity of ethanobotnical plants used as. Medicinal plants with antiinflammatory activities from. The methanolic extract at the dose level of 400 mgkg body weight and diclofenac sodium at the dose of 5 mgkg exhibit significant p oct, 2011. The signs of inflammation are redness elevated heat, swelling, pain, loss of function. The topical anti inflammatory activity of sesquiterpenes is. Anti inflammatory activity of artocarpus heterophyllus bark extracts against carragenan induced paw edema is shown in table 1.
The digital thesis deposit has been a graduation requirement since 2006. Anti inflammatory studies were conducted in rats on an ethanol extract of whole plant euphorbia prostrata and its partitioned fractions. Assessment of the antiinflammatory activity of potentially. This thesis explores the role of inflammation in human tendinopathy and dissects potential molecular pathways involved in its initiation and perpetuation. Antiinflammatory activity of ethanobotnical plants used.
Chilli pepper extract was shown to have the strongest antiinflammatory activity along with allspice, apple. Diclofenac 20 mgkg was used as standard for both the models. In vitro and in vivo antiinflammatory activity of extracts. The antiinflammatory activity may be attributed to the presence of the forementioned bioactive compounds. Only then can true growth and development thrive worldover. Antiinflammatory activity of natural products mdpi. Emphasis was put on identifying the mode of action of the anti inflammatory component, creating an in vitro assay to measure the anti inflammatory activity of individual honeys and attempting to identify and characterise the. The methanolic extract at the dose level of 400 mgkg body weight and diclofenac sodium at the dose of 5 mgkg exhibit significant p anti. The anti inflammatory activity was evaluated by in vivo models like carrageenaninduced rat hind paw edema and acetic acid induced vascular permeability in mice using dose levels of. Nonsteroidal antiinflammatory drugs and peptic ulcers. Emphasis was put on identifying the mode of action of the antiinflammatory component, creating an in vitro assay to measure the antiinflammatory activity of individual honeys and attempting to identify and. Nmethyldaspartate receptor antagonism decreases motility and inflammatory activation in the early phase of acute experimental colitis in the rat.
A study of antimicrobial activity of few medicinal herbs. All compounds were also tested in vitro for anti hiv activity. The antiinflammatory activity was found to be dose dependent in carrageenaninduced paw edema model. Anti inflammatory activity of medicinal plants thesis proposal. The role of inflammation and cytokines in the pathogenesis. The potential activity of extract may be due to the presence of phenols, flavonoids and other phytochemical constituents present in it. The molecular pathophysiology of tendinopathy remains difficult to interpret while inflammation and its role in tendinopathy have been historically ignored due to its absence in human surgical specimens. Oct, 2011 the reported antiinflammatory mechanisms included reduction of the proinflammatory cytokines il6 and tnf. They possess different activities like antibacterial, antifungal, anti inflammatory and anti tumor etc depending on the sub.
Thesis institute of surgical research, university of szeged 20. Starting in 2012, alumni of the yale school of medicine were invited to participate in the ymtdl project by granting scanning and hosting permission to the cushingwhitney medical library, which digitized the librarys print copy of their thesis or dissertation. To evaluate the acute and chronic antiinflammatory properties of leaf extracts of kalanchoe crenata in rats. Antiinflammatory activity an overview sciencedirect topics. From the gunapadam aspects, journals abstracts and other literatures surveys the author had an idea about the therapeutic efficacy. The biochemical analysis revealed that the drug contains ferrous iron. The role of nutrition in health promotion and disease prevention programs, j am diet assoc, 98.
Turmeric curcuma longa, which has traditionally been used for treatment of rheumatic disorders in indian traditional medicine, exerts both anti inflammatory and anti atherosclerotic effects krishnaswamy, 2008. In vivo studies for anti inflammatory activity is performed by carrageen induced rat paw edema technique. Masters thesis, dalhousie university, halifax, ns, canada, 2012. This thesis addresses several issues related to the pathogenesis of peptic ulcers in patients receiving nonsteroidal anti inflammatory drugs nsaid. The antinociceptive and anti inflammatory activities of the extract were compared to those of diclofenac while the antipyretic activity of the extract was compared. I hereby declare that the experimental work described in this thesis was carried out by me at the. The antiinflammatory activity of hydroalcoholic extract of sphearanthus indicus herb was done by using various experimental models. The dose of thandrikkai chooranam is 1 gram with luke warm water, thrice a day after meals. The anti inflammatory activity of hydroalcoholic extract of sphearanthus indicus herb was done by using various experimental models.
Cfr methanol extract exhibited anti inflammatory activity both in vitro and in vivo. Thus from the above results it was concluded that the aekkc showed anti oxidant activity and promising anti inflammatory, antipyretic and antibacterial activity. Botanical aspects showed the identification description and chemical constituents of the plant. Name of herb family part used phytoconstituents isolated reference 1 achillea millefolium linn. Antiinflammatory, antipyretic and antibacterial study of. The study of the antiinflammatory activity of eforan. Pdf research paper antiinflammatory activity of leaf extracts of. Formulation and evaluation of topical herbal gel for the. Anti inflammatory activity of medicinal plants thesis. This article provides detailed, systematic information about a large number of mushroom species, many biologically active compounds, and importantly, suggested mechanisms of action. A thesis submitted in partial fulfillment of the requirements for the award of the degree of master of science medical biochemistry in the school of. The aqueous extract has shown significant p on 4 th hour at the doses of 200 and 400 mgkg, respectively. We introduce some herbs which their antiinflammatory effects have been evaluated in. Antioxidant and antiinflammatory activities of the methanolic leaf.
In addition, wound healing and detoxifying properties of. Tamil nadu certificate this is to certify that the dissertation work entitled antiinflammatory, antipyretic and antibacterial study of kabasura kudineer choornam is a bonafide work carried out by reg. Firstly i characterize inflammatory cell subtypes within a model of human tendinopathy highlighting a distinct inflammatory infiltrate particularly of mast cells and macrophages. The topical antiinflammatory activity of sesquiterpenes is. Antiinflammatory, analgesic, and antipyretic activities of. The ethyl acetate fraction in an oral dose of 200 mgkg. Thesis synthesis, characterization and antiinflammatory evaluation of new potentially active naproxen hydrazones thesis pdf available december 2015 with 2,324 reads how we measure reads. They possess different activities like antibacterial, antifungal, antiinflammatory and anti tumor etc depending on the sub. Formulation and evaluation of topical herbal gel for the treatment of arthritis in animal model 495 quality control of topical herbal gel formulation estimation of active constituents in gel formulation net content each formulation 1 g was taken in a 50 ml volumetric flask and made up to volume with methanol and.
Herein, we report the isolation, structural elucidation, and results from anti inflammatory and anti hiv. The antiinflammatory action of tetracyclines aston. A study on anti inflammatory and analgesic activity of. The antiinflammatory effect was evaluated for plant extracts 100,200 and 500 mgkg orally using acute inflammatory model, carrageenan induced paw oedema in rats. Antiinflammatory activity of the leaf extacts of gendarussa. Thesis synthesis, characterization and antiinflammatory. In acute inflammatory models, vco showed moderate antiinflammatory effects on ethyl phenylpropiolateinduced ear edema in rats, and carrageenin and arachidonic acidinduced paw edema. The antiinflammatory effects of tetracycline drugs have been investigated in the context of a range of inflammatory diseases including sepsis and a number of neurodegenerative diseases. Thesis synthesis, characterization and antiinflammatory evaluation of new potentially active naproxen hydrazones. Antioxidant and potential antiinflammatory activity of. Termination of the inflammatory response is mediated by intrinsic antiinflammatory mechanisms that limit tissue damage and allow for either restoration of tissue, with return to normal physiological function, or repair and the development of scar in place of normal tissue. This thesis explores the role of inflammation in human. Viana et al, 1997 several thesis, pharmacology, university of nigeria, nsukka, nigeria ezekwesili c phytochemical study and antiinflammatory, pdf jan 2012 this paper is taken in part from the ph d thesis of m ngeles ramrez. Ldso was calculated by plotting the probit log dose response curve ghosh, 1971.
Biomedical sciences i56ctypt271052014 a thesis submitted in partial fulfillment of the requirements for the award. Emphasis was put on identifying the mode of action of the anti inflammatory component, creating an in vitro assay to measure the anti inflammatory activity of individual honeys and attempting to identify and characterise the components responsible for the activity. Study of antiinflammatory activity in the leaves of. Many of them are found in the socalled mediterranean diet, which emphasizes fish. Phytochemical analysis, antiinflammatory and analgesic. Hence anti inflammatory activity of the extracts was concentration dependent. The anti inflammatory activity was found to be dose dependent in carrageenaninduced paw edema model.
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